Showing posts with label science. Show all posts
Showing posts with label science. Show all posts

Wednesday, May 2, 2018

Science, Fibromyalgia, and Exercise


Courtesy Pexels.com

Last year I wrote about the importance of critical thinking and problem solving and casting a light on recurring theories. This year, I decided to kick off a review of the research beginning with a look at exercise and fibromyalgia.
                                
In my 2015 blog, I asked "Can Aerobic Exercise Reduce Fibromyalgia Symptoms?" As I said, the answer is tricky because there is evidence that aerobic exercise can reduce symptoms, and there is evidence to suggest it can increase symptoms. So, maybe we should look at the evidence on different types of exercise, like warm water (aquatic) exercise, yoga and stretching, and aerobic exercise vs. tai chi.
                                                                                   
AQUATIC EXERCISE

Using assessment parameters we usually see when studying fibromyalgia, researchers (2008) looked at the effectiveness of aquatic (warm water) therapy compared to home based exercise therapy.  They found that both aquatic therapy and home-based exercise programs have beneficial effects. However, when considering pain management, only aquatic therapy had longer lasting effects. And, a 2015 study revealed that a pool-based aquatic aerobic exercise program was the most effective treatment when compared to isometric strength-stretching and aerobic exercise. So, can we conclude aquatic therapy is good for fibromyalgia, maybe not?

In 2014, Bidonde J, et al. concluded that there is low to moderate quality evidence to suggest that aquatic training is beneficial. And “very low to low quality evidence suggests that there are benefits of aquatic and land-based exercise, except in muscle strength (very low quality evidence favoring land)”. What are we to think? 

Ai Chi = The use of breathing techniques and progressive resistance training in water to relax and strengthen the body, based on elements of qigong and Tai chi chuan.

I personally found aquatic therapy made my myofascial pain syndrome pain much worse. Enter Ai Chi. Knowing my past experience, my physical therapist encouraged me try Ai Chi. Trusting in him, I did. It is very different and I liked it. So, it comes as no surprise to me that a 2016 pilot study found “significant differences in values such as pain perception, vitality, mental health, as well as perceived overall improvement in quality of life”. This new approach (Ai Chi), rather than aquatic strength training, may make a difference in the benefits of warm water therapies. 

RESISTANCE EXERCISE

Research on resistance training (isometrics, weight training, etc.) is reported by the experts to be of low quality, so I am not entertaining it here.

STRETCHING AND YOGA

A 2014 Brazilian review, Effects of muscle stretching exercises in the treatment of fibromyalgia, found significant improvement in all studies regarding pain and quality of life. However, they concluded that even though it is clear that muscle stretching for fibromyalgia is important, there is a need for further studies because of the low quality of methods used and the lack of standardization for comparative analysis. This makes it difficult to know if a certain stretching technique is better.

What about yoga?

A 2011 pilot study suggests a protocol for managing fibromyalgia with yoga and meditation. While they do report positive responses, there were only 11 participants.

Courtesy Pexels.com

Side note: I do a few gentle flowing yoga poses as a warm up to tai chi. If my chest feels restricted, I get right to breathing through the child’s pose. Tree pose is my barometer for knowing when I need to work on balance before I do something stupid, like fall over for no reason, or sling my arms into walls, what I call in our BIG book, the “Bull in the China Cabinet Effect.” I have learned that holding postures will activate trigger points and cause mind-altering pain. But, stretching can feel so good; and when it’s done right, it should.


A small 2017 mindful yoga pilot study found fibromyalgia symptoms and functional deficits improved significantly, as did physical tests of strength and balance, and pain coping strategies. These findings indicate that further investigation is warranted into the effect of Mindful Yoga on neurobiological pain processing.”

AEROBIC EXERCISE vs. TAI CHI        

Aerobic exercise is often suggested as a first line treatment for fibromyalgia. However, as recently as 2017 that could change. In a review, researchers report those of us with fibro may see little to no difference in our pain and physical function from aerobic exercise. Quote, “We downgraded the evidence owing to the small number of included trials and participants across trials, and because of issues related to unclear and high risks of bias (performance, selection, and detection biases). Aerobic exercise appears to be well tolerated (similar withdrawal rates across groups), although evidence on adverse events is scarce, so we are uncertain about its safety.” There is some research to suggest the way our body responds to exertional demands could play a role in our intolerance to aerobic exercise, such as running, biking, or other physical activities that increase our heart rate.

Balancing Rocks-Celeste's Photography
There is a great deal of evidence to suggest tai chi is beneficial for improving fibromyalgia symptoms and mobility.  Maybe that’s because our autonomic nervous system tolerates the gentle movements of tai chi better than aerobic exercise. A randomized controlled trial published on March 23, 2018 looked at the effects of tai chi training in relationship to heart rate variability, symptoms, and muscle fitness in women with fibromyalgia and suggest tai chi may be effective for improving autonomic balance, pain, fatigue, strength and flexibility in women with fibromyalgia. And, a study published March 21, 2018 found “tai chi mind-body treatment results in similar or greater improvement in symptoms than aerobic exercise”.

It’s important for anyone with chronic pain to keep moving. And, when it comes to fibromyalgia, it appears the positive results are more likely if the practice of mindfulness is included with exercise.

Additional Reading:

A Year of Fibro: Musings, Writings, and Opinions, May 2016. A recap of my writings on fibromyalgia


In healing,

Celeste Cooper, RN / Author, Freelancer, Advocate

Think adversity?-See opportunity!



~ • ~ • ~ • ~ • ~ • ~

Learn more about Celeste’s books here. Subscribe to posts by using the information in the upper right hand corner or use the share buttons to share with others. 

Friday, March 8, 2013

Biological marker for fibromyalgia is challenged- No surprise



A unique immunological pattern has been found in fibromyalgia in a study done by Behm, et al, 2012. Full article in pdf here.

"The cytokine responses to mitogenic activators of PBMC isolated from patients with FM were significantly lower than those of healthy individuals, implying that cell-mediated immunity is impaired in FM patients. This novel cytokine assay reveals unique and valuable immunologic traits, which, when combined with clinical patterns, can offer a diagnostic methodology in FM."
Bruce Gillis, MD, and member of the clinical faculty at the University of Illinois, Chicago College of Medicine, has taken the results of this study of which he was a part, to another level. He has developed a blood analysis, the FM/a® Test, which is capable of diagnosing FM. (Dr Gillis is the founder of the Epic Genetics, where the blood test is conducted.) 

As I read the study and the following publications, I braced for what I knew would follow.

Questions arise over new diagnostic test for fibromyalgia
http://www.foxnews.com/health/2013/02/26/questions-arise-over-new-diagnostic-test-for-fibromyalgia/#ixzz2My2kMd9N

As with all good science comes challenge, as it should. I agree with Dr Daniel Clauw that replicated studies are necessary.  Dr. Gillis may or may not have jumped the gun on objective blood test, but the evidence is significant.  Though this is the first study of its kind, it certainly is not the first study suggesting that diminished cytokine response has been implicated in fibromyalgia. Consistent cytokine abnormalities, though none as significant as seen in this study, suggest an immunological factor. This would explain why fibromyalgia clusters with other neuro-endocrine-immunologic disorders.  

As I have written, yet to be published, this is the beginning of some very interesting research.  Investigations that will move us down the right path.  It does not negate the involvement of the HPA axis in FM.  My opinion is that neuroimmunologic science suggests it is part of it.  When the hypothalamus-pituitary axis is dysfunctional, as seen in repeated studies of FM, it affects the neuro-endocrine and immunologic responses, and involvement of the autonomic nervous system.  We know the central nervous system is bombarded with chronic pain impulses from the periphery (from conditions such as  myofascial pain syndrome, known muscle abnormalities, or from cervical nerve root impingement another pain impulse aggravator suggested in FM). The fibromyalgia brain does not respond the same way when compared to other chronic pain disorders.  Many people with chronic pain share centralization, which is amplification of pain, but do not have any of the comorbid disorders associated with fibromyalgia. That is where the difference lies, that is the defining factor of HPA dysfunction resulting in neuro-endocrine and immunologic responses. 

Dr Frederick Wolfe suggests that these same results might be found in other illnesses.  This bears mentioning and I agree.  We need more research.  However, this study does suggest that fibromyalgia patients do have an immune dysfunction, whether it shares the same immune dysfunction with other illnesses is up for debate. I believe we need to focus on this, it proves that fibromyalgia is a biological disorder." Dr. Clauw and Dr. Robert Bennett, Dr. Roland Staud, and many others who have studied fibromyalgia diligently for many years all agree that fibromyalgia is NOT a psychological disorder.

Dr. Dan Wallace, a clinical professor of medicine at the David Geffen School of Medicine at UCLA based at Cedars-Sinai Medical Center,  says,

“The elegantly designed study by Dr. Gillis and his co-investigators represents a milestone on the path our group charted 25 years ago when we first hypothesized that cytokines play a role in fibromyalgia. It is hoped that this and future work sponsored by EpicGenetics will lead to a greater understanding of how the immune system, fatigue, sleep disorders, chronic stress and pain interact in patients with fibromyalgia and related disorders.”
Here is the hope in this message.   I feel optimistic that this biological marker will prove itsself because of the significant results between the FM and the healthy control group in the study. Fibromyalgia can no longer be seen as a psychosomatic disorder.  We will not have to be concerned about an ICD classification, or how fibromyalgia could be interpreted by the APA (American Psychiatric Association) Diagnostic and Statistical Manual of Mental Disorders, DSM-5. (See Who is the WHO, and Why does it Matter to You?).   Why is this important? Because these classifications are used to track data, ultimately determine treatment/referrals, and insurance reimbursement.

Fibromyalgia is now recognized in the Social Security Administration Blue Book, “Listing of Impairments,” and having a biological marker, whether specific to fibromyalgia or not, is a really big deal for the lives of many fibromyalgia patients whose symptoms are so severe they are no longer able to work. 

Yes, a glorious storm is brewing.  I am jubilant, even giddy, because, without adversity there is no opportunity.” Questions such as those proposed and those yet to come deserve merit, it means we will see more target rich research.  We will continue on in our current treatment plan, just as those with other syndromes, such as rheumatoid arthritis, systemic lupus erythematosus, and many others for which we have no cure.  The test may be cost prohibitive and maybe we should exercise patience until replicated and larger studies are implemented. If it bears out, then insurance companies should not deny reimbursement. But until then, this research and the test developed by Dr. Gillis is a really BIG deal, researchers have been working on a biological marker, have felt it was around the corner and the corridor of light could be staring us straight in the face, there is hope.

In healing and hope, Celeste

For more information on the test
www.thefmtest.com
www.epicgtx.com

All answers and blogs are based on the author's opinions and writing and are not meant to replace medical advice.  For more information about the author see http://TheseThree.com

Resources:

Alonso-Blanco C, Fernández-de-las-Peñas C, Morales-Cabezas M, Zarco-Moreno P, Ge HY, Florez-García M. Multiple active myofascial trigger point reproduce the overall spontaneous pain pattern in women with fibromyalgia and are related to widespread mechanical hypersensitivity. Clin J Pain. 2011 Jun;27(5):405-13.

Behm FG, Gavin IM, Karpenko O, Lindgren V, Gaitonde S, Gashkoff PA, Gillis BS. Unique immunologic patterns in fibromyalgia. BMC Clin Pathol. 2012 Dec 17;12(1):25. doi: 10.1186/1472-6890-12-25.

Bennett RM, Goldenberg DL. 2011. Fibromyalgia, myofascial pain, tender points and trigger points: splitting or lumping? Arthritis Res Ther. 2011 Jun 30;13(3):117.

Caro XJ, Winter EF, Dumas AJ., “A subset of fibromyalgia patients have findings suggestive of chronic inflammatory demyelinating polyneuropathy and appear to respond to IVIg,” Rheumatology 47, no. 2 (2008): 208–11.

Fibromyalgia and Chronic Pain Life, Cover article, Mar/April 2013
http://www.joomag.com/magazine/fibromyalgia-chronic-pain-life-mar-apr-2013-i/0674007001362475699

Ge HY, Wang Y, Danneskiold-Samsøe B, Graven-Nielsen T, Arendt-Nielsen L. The predetermined sites of examination for tender points in fibromyalgia syndrome are frequently associated with myofascial trigger points. J Pain. 2010 Jul;11(7):644-51. Epub 2009 Nov 14.

Geiss A, Rohleder N, Anton F. Evidence for an association between an enhanced reactivity of interleukin-6 levels and reduced glucocorticoid sensitivity in patients with fibromyalgia. Psychoneuroendocrinology. 2011 Oct 13. [Epub ahead of print]

Gerdle B, Forsgren MF, Bengtsson A et al. 2013. Decreased muscle concentrations of ATP and PCR in the quadriceps muscle of fibromyalgia patients – A (31) P-MRS study. Eur J Pain. [Jan 30 Epub ahead of print]. [Once again, what about looking at knotted up pieces of muscle fiber, called trigger points/MTrPs, which have histological changes? Cc]

Holman AJ. Positional cervical spinal cord compression and fibromyalgia: a novel comorbidity with important diagnostic and treatment implications. J Pain. 2008 Jul;9(7):613-22. doi: 10.1016/j.jpain.2008.01.339. Epub 2008 May 22.

Kadetoff D, Lampa J, Westman M, Andersson M, Kosek E. Evidence of central inflammation in fibromyalgia –Increased cerebrospinal fluid interleukin-8 levels.  J Neuroimmunol. 2011 Nov 27.

Macedo, J.A., Hesse, J., Turner, J.D., Ammerlaan, W., Gierens, A., Hellhammer, D.H., Muller, C.P. (2007, Aug). Adhesion molecules and cytokine expression in fibromyalgia patients: increased L-selectin on monocytes and neutrophils. J Neuroimmunol., 188(1-2), pp. 159-166.

Sorenson M, Jason L, Lerch A, Porter N, Peterson J,  and Mathews H, "The Production of Interleukin-8 is Increased in Plasma and Peripheral Blood Mononuclear Cells of Patients with Fatigue," Neuroscience & Medicine, Vol. 3 No. 1, 2012, pp. 47-53.

Light AR, Bateman L, Jo D, Hughen RW, Vanhaitsma TA, White AT, Light KC. J Intern Med. 2011 May 26. doi: 10.1111/j.1365-2796.2011.02405.x. [Epub ahead of print] 

Srikuea R, Symons TB, Long DE, Lee JD, Shang Y, Chomentowski PJ, Yu G, Crofford LJ, Peterson CA. Fibromyalgia is associated with altered skeletal muscle characteristics which may contribute to post-exertional fatigue in post-menopausal women. Arthritis Rheum. 2012 Nov 1. 

Monday, December 5, 2011

Nerve to Muscle and the Role in Fibromyalgia

Research continues to tell us that fibromyalgia involves the breakdown of normal messaging in the brain, which is further sensitized by peripheral nervous system dysfunction, particularly in the muscle. This results in what is known as centralization of pain.

Chronic myofascial pain from myofascial trigger points which are caused by an excessive release of acetylcholine, a chemical neuro messenger, is prevalent in fibromyalgia and helps explain muscle pain and dysfunction. Myofascial trigger points are known as the great neurological imitators. When coupled with fibromyalgia this peripheral input further sensitizes the brain and it becomes a vicious cycle.

Learn more about chronic myofascial pain.

It is difficult to deny the brains ability to resurrect previous pain experiences or detach the emotional center from the physical response. Conditioning responses is important and why treatment takes a multidimensional approach. These various treatments, medication, stretching movement such as Yoga, gradual exercise after bringing myofascial trigger points under control, meditation, T’ai Chi for promoting balance input to the brain are all important for putting a tire tool in the spokes of this wheel spinning out of control between the brain and the periphery.


All blogs, posts and answers are based on the work in Integrative Therapies for Fibromyalgia, Chronic Fatigue Syndrome, and Myofascial Pain: The Mind-Body Connection by Celeste Cooper, RN, and Jeff Miller, PhD. 2010, Vermont: Healing Arts press and are not meant to replace medical advice. Website


This blog is based on my original answer at ShareCare, What role do nerves play in fibromyalgia? View my other answered questions as fibromyalgia expert.


Resources

Affaitati G, Costantini R, Fabrizio A, Lapenna D, Tafuri E, Giamberardino MA.Effects of treatment of peripheral pain generators in fibromyalgia patients. Eur J Pain. 2011 Jan;15(1):61-9.

Bazzichi L, Rossi A, Massimetti G, Giannaccini G, Giuliano T, De Feo F, Ciapparelli A, Dell'Osso L, Bombardieri S.Cytokine patterns in fibromyalgia and their correlation with clinical manifestations. Clin Exp Rheumatol. 2007 Mar-Apr;25(2):225-30.

Bennett, R. Understanding Chronic Pain and Fibromyalgia: A Review of Recent Discoveries
National Fibromyalgia and Chronic Pain Association: The Science of Fibromyalgia http://fmcpaware.org/science-of-fm

Burgmer M, Gaubitz M, Konrad C, Wrenger M, Hilgart S, Heuft G, Pfleiderer B.
Decreased gray matter volumes in the cingulo-frontal cortex and the amygdala in patients with fibromyalgia. Psychosom Med. 2009 Jun;71(5):566-73. Epub 2009 May 4.

Carvalho LS, Correa H, Silva GC, Campos FS, Baião FR, Ribeiro LS, Faria AM, d'Avila Reis D.
May genetic factors in fibromyalgia help to identify patients with differentially altered frequencies of immune cells? Clin Exp Immunol. 2008 Dec;154(3):346-52.

Castro-Sanchez AM, Mataran-Penarrocha GA, Granero-Molina J et al. 2011. Benefits of massage-myofascial release therapy on pain, anxiety, quality of sleep, depression, and quality of life in patients with fibromyalgia. Evid Based Complement Alternat Med. 2011:561753.

Clauw DJ, Arnold LM, McCarberg BH; for the FibroCollaborative. The Science of Fibromyalgia Mayo Clin Proc. 2011 Sep;86(9):907-911.

Ge HY, Wang Y, Danneskiold-Samsøe B, Graven-Nielsen T, Arendt-Nielsen L. The predetermined sites of examination for tender points in fibromyalgia syndrome are frequently associated with myofascial trigger points. J Pain. 2010 Jul;11(7):644-51. Epub 2009 Nov 14.

Hubbard JE. Myofascial Trigger Points: What Physicians Should Know about these Neurological Imitators Minn Med. 2010 May;93(5):42-5.

Lee YC, Nassikas NJ, Clauw DJ. The role of the central nervous system in the generation and maintenance of chronic pain in rheumatoid arthritis, osteoarthritis and fibromyalgia.
Arthritis Res Ther. 2011 Apr 28;13(2):211. [Epub ahead of print]

Lyon P, Cohen M, Quintner J. An evolutionary stress-response hypothesis for chronic widespread pain (fibromyalgia syndrome). Pain Med. 2011 Aug;12(8):1167-78. doi: 10.1111/j.1526-4637.2011.01168.x. Epub 2011 Jun 21.

Macedo JA, Hesse J, Turner JD, Ammerlaan W, Gierens A, Hellhammer DH, Muller CP.
Adhesion molecules and cytokine expression in fibromyalgia patients: increased L-selectin on monocytes and neutrophils. J Neuroimmunol. 2007 Aug;188(1-2):159-66. Epub 2007 Jun 28.

Petersel DL, Dror V, Cheung R. Central amplification and fibromyalgia: disorder of pain processing. J Neurosci Res. 2011 Jan;89(1):29-34.

Celeste's Website

Celeste's Website
Click on the picture